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Cytotoxic activity characterization of RNase3/1.
| IC50 (μM) |
|||
|---|---|---|---|
| RNase 1 | RNase 3 | RNase 3/1 | |
| Lung fibroblasts (MRC-5) | N.D. | >100 | N.D. |
| Hepatocarcinoma epithelial cells (HepG2) | N.D. | 134.66 ± 0.95 | N.D. |
IC50 was determined as the concentration of protein where 50% of cells were still alive. Cytotoxicity was determined by the MTT assay. Each assay was performed in triplicate. N.D. means that, at the highest tested concentration (200 μM), no reduction of cell viability was detected.
