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. 2019 Jun 19;6:81. doi: 10.3389/fcvm.2019.00081

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Copyright © 2019 Bax, Duim, Kruithof, Smits, Bouten and Goumans.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Human collagen type I is present in the infarcted NOD-SCID mouse heart after hEPDC injection. (A) Two days after injection of hEPDCs (green) in the mouse infarcted heart, human collagen I (red) is present. The expression of human collagen I (red) increased at day 4 (B) and 7 (C) after MI. (D). After 6 weeks, hEPDCs (green) were still present in the infarcted mouse heart. At this time point, the total amount of collagen I (white) was prominent, while the amount of human collagen type I (red) was markedly reduced. Images (A'–D') represent location of hEPDCs (green) and human collagen I (red) and images (A”–D”) represent enlargements of images (A'–D'). Scale bar 250 μm.