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. 2019 Jun 19;6:81. doi: 10.3389/fcvm.2019.00081

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Copyright © 2019 Bax, Duim, Kruithof, Smits, Bouten and Goumans.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Extracellular matrix (ECM) proteins are synthesized by hEPDCs. Validation of qPCR data on the expression of ECM genes collagen I (A) collagen III (B), and fibronectin (C) revealed induction of these genes under exposure to uniaxial cyclic strain. These data are represented as mean fold increase ± SD. Since the average ΔCt of the unstrained samples was used as calibrator, the fold change (2^ΔΔCt) of the unstrained group is close to 1.0. Representative fluorescent images confirm the biosynthesis of these ECM proteins collagen I (D), collagen III (E), fibronectin (F), and elastin (G) in red, co-stained by cell surface markers CD44 (D′), and β1 Integrin (E′-G′) both in green. **P < 0.01. Scale bar 50 μm.