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. 2019 Jun 19;6:81. doi: 10.3389/fcvm.2019.00081

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Copyright © 2019 Bax, Duim, Kruithof, Smits, Bouten and Goumans.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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TGFβ signaling is induced in hEPDCs exposed to uniaxial cyclic strain. Gene expression of unstrained and strained hEPDCs showed that the expression of Pai-1 was increased by application of strain (A). Gene expression of hEPDCs exposed to strain in the presence of iALK5 showed a significant decrease in Pai-1. Inhibition of TGFβ signaling also resulted in a significant downregulation of collagen I (B,D,D'), while no significant change was found in the expression of collagen III (C,E,E'). The data are represented as mean fold change ± SD. *P < 0.05, **P < 0.01.