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. Author manuscript; available in PMC: 2019 Jun 26.
Published in final edited form as: Acta Radiol. 2010 Oct;51(8):910–923. doi: 10.3109/02841851.2010.502126

Fig. 8.

Fig. 8

The amide protons of Yb-DOTAM complexes (structure on the right) exhibit a CEST effect that is highly pH dependent. By incorporating these PARACEST agents onto a dendrimer the pH range not only increases sensitivity but allows the pH range over which CEST changes to be tuned.