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. Author manuscript; available in PMC: 2019 Dec 19.
Published in final edited form as: J Am Chem Soc. 2018 Dec 11;140(50):17456–17464. doi: 10.1021/jacs.8b07607

Figure 1.

Figure 1.

(A) Chemical structures of GdDO3A-monoBPEN (GdL1) or monoPEPMA derivatives (GdL2). (B) Simplified illustration of the formation of a ternary complex, GdL-Zn-HSA. (C) Proton relaxation enhancement titrations of each complex (GdL1 and GdL2, 0.1 mM) as a function of increasing [HSA]. [Zn2+] was held constant (0.6 mM, equal to the highest concentration of HSA) in each titration. All measurements were performed at 0.5 T, 37 °C in 100 mM Tris buffer at pH 7.