Table 2.

Association of neighborhood problems and social cohesion scores with >30% decline in eGFR since baseline stratified by race/ethnicity, MESA 2000–2002

	N	% with decline	HR (95% CI)
			Model 1c	Model 2d	Model 3e
Neighborhood Problems Scorea
All
Q1	1468	11	1.00 (reference)	1.00 (reference)	1.00 (reference)
Q2	1477	12	1.11 (0.87, 1.38)	0.94 (0.75, 1.19)	0.93 (0.74, 1.17)
Q3	1481	13	1.18 (0.95, 1.47)	1.02 (0.82, 1.29)	0.97 (0.77, 1.22)
Q4	1466	13	1.21 (0.97, 1.51)	1.03 (0.82, 1.30)	0.98 (0.78, 1.24)
White
Q1	504	10	1.00 (reference)	1.00 (reference)	1.00 (reference)
Q2	628	11	1.09 (0.75, 1.58)	1.12 (0.77, 1.63)	1.07 (0.73, 1.56)
Q3	776	12	1.25 (0.88, 1.78)	1.29 (0.91, 1.83)	1.25 (0.87, 1.78)
Q4	434	10	0.88 (0.57, 1.35)	0.99 (0.64, 1.53)	0.99 (0.64, 1.54)
Black
Q1	193	8	1.00 (reference)	1.00 (reference)	1.00 (reference)
Q2	468	18	0.82 (0.53, 1.27)	0.74 (0.48, 1.16)	0.77 (0.49, 1.19)
Q3	400	14	0.95 (0.62, 1.48)	0.85 (0.55, 1.32)	0.81 (0.52, 1.27)
Q4	527	16	1.07 (0.71, 1.61)	0.93 (0.61, 1.41)	0.87 (0.57, 1.32)
Chinese
Q1	457	7	1.00 (reference)	1.00 (reference)	1.00 (reference)
Q2	118	10	1.38 (0.70, 2.73)	1.32 (0.66, 2.65)	1.21 (0.58, 2.53)
Q3	64	11	1.35 (0.57, 3.22)	1.26 (0.52, 3.05)	1.07 (0.43, 2.66)
Q4	53	4	0.53 (0.13, 2.20)	0.39 (0.09, 1.65)	0.39 (0.09, 1.65)
Hispanic
Q1	341	13	1.00 (reference)	1.00 (reference)	1.00 (reference)
Q2	263	11	0.82 (0.50, 1.35)	0.80 (0.49, 1.31)	0.80 (0.48, 1.33)
Q3	241	9	0.58 (0.33, 1.02)	0.66 (0.38, 1.16)	0.63 (0.35, 1.12)
Q4	452	12	0.91 (0.60, 1.38)	1.04 (0.68, 1.59)	1.08 (0.70, 1.66)
Neighborhood Social Cohesion Scoreb
All
Q4	1456	12	1.00 (reference)	1.00 (reference)	1.00 (reference)
Q3	1492	12	0.99 (0.79, 1.23)	0.98 (0.78, 1.22)	0.94 (0.75, 1.17)
Q2	1472	11	0.89 (0.71, 1.11)	0.96 (0.76, 1.21)	0.92 (0.73, 1.16)
Q1	1472	14	1.14 (0.92, 1.41)	1.07 (0.85, 1.35)	1.01 (0.80, 1.27)
White
Q4	923	11	1.00 (reference)	1.00 (reference)	1.00 (reference)
Q3	597	11	1.06 (0.77, 1.45)	1.01 (0.74, 1.39)	0.99 (0.72, 1.36)
Q2	595	10	0.92 (0.66, 1.28)	0.99 (0.71, 1.38)	1.02 (0.73, 1.43)
Q1	227	13	1.22 (0.80, 1.86)	1.14 (0.75, 1.74)	1.18 (0.77, 1.81)
Black
Q4	444	15	1.00 (reference)	1.00 (reference)	1.00 (reference)
Q3	380	16	1.07 (0.73, 1.55)	0.91 (0.63, 1.33)	0.81 (0.56, 1.19)
Q2	253	17	1.10 (0.73, 1.65)	0.95 (0.63, 1.43)	0.79 (0.52, 1.20)
Q1	511	17	1.12 (0.80, 1.57)	0.98 (0.69, 1.38)	0.86 (0.61, 1.22)
Chinese
Q4	32	3	1.00 (reference)	1.00 (reference)	1.00 (reference)
Q3	184	7	2.21 (0.29, 16.97)	1.95 (0.25, 15.03)	1.93 (0.24, 15.38)
Q2	246	7	2.13 (0.28, 16.11)	1.81 (0.23, 13.93)	2.28 (0.29, 17.84)
Q1	230	11	3.70 (0.50, 27.34)	2.65 (0.035, 19.92	2.75 (0.36, 21.19)
Hispanic
Q4	57	12	1.00 (reference)	1.00 (reference)	1.00 (reference)
Q3	331	12	0.88 (0.39, 1.98)	0.92 (0.40, 2.07)	1.00 (0.43, 2.32
Q2	378	11	0.86 (0.39, 1.93)	0.90 (0.40, 2.03)	0.94 (0.41, 2.15)
Q1	504	12	0.92 (0.42, 2.02)	0.95 (0.43, 2.12)	1.01 (0.45, 2.30)

N=5892.

^aThe coefficients for the neighborhood problems score represent the risk of a >30% decrease in eGFR over the ten-year period comparing each quartile to quartile 1 (Q1). Quartiles of the neighborhood problems score are: Q1≤1.32, Q2=1.33–1.47, Q3=1.48–1.63, Q4≥1.64.

^bThe coefficients for the neighborhood social cohesion score represents the risk of a >30% decrease in eGFR over the ten-year period comparing each quartile to Q1. Quartiles of the social cohesion score are: Q1≤3.42, Q2=3.43–3.52, Q3=3.53–3.69, Q4≥3.70.

^cModel 1 is unadjusted.

^dModel 2 includes adjustment for age, gender, race/ethnicity (in models with the total sample only), income, education, and MESA site.

^eModel 3 includes further adjustment for diabetes, hypertension, smoking, BMI, LDL, HDL, CRP, and UACR.

Abbreviations: CI, confidence interval; eGFR, ________; HR, hazard ratio; MESA, _____.