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. 2019 Jun 19;10:803. doi: 10.3389/fpls.2019.00803

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Copyright © 2019 Ibrahim, Odon and Kormelink.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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A schematic representation of wild type VSV and recombinant VSV designs. (A) 3′ to 5′ negative-strand genomic RNA organization of wild type VSV. (B) Recombinant VSV (rVSV) with foreign protein inserted between the VSV G and L genes. (C) rVSV with foreign protein fused to the inherent VSV glycoprotein. (D) Recombinant VSVΔG with foreign protein replacing the inherent VSV glycoprotein. (E) rVSV with foreign protein gene inserted upstream of the VSV N protein. (F) rVSV with the gene for foreign protein inserted upstream of the VSV N protein and with truncated VSV glycoprotein. le, leader; tr, trailer; insP, gene for inserted protein; Gtrc, truncated glycoprotein.