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. 2019 Jun 19;10:1369. doi: 10.3389/fmicb.2019.01369

TABLE 2.

Compilation of references mentioning the main pathologic manifestations of malaria in pregnancy observed in humans and murine models.

Human MiP Murine MiP
Pregnancy outcome

Recrudescence Giobbia et al., 2005; Mayor et al., 2009; Laochan et al., 2015; Al Hammadi et al., 2017; Malvy et al.,2018 van Zon and Eling, 1980; Oduola et al., 1982; van Zon et al., 1982, 1985; Marinho et al., 2009; Megnekou et al., 2009; Sharma et al.,2016

Anemia Brabin et al., 2001; Rogerson et al.,2003 Oduola et al., 1982; Desowitz et al., 1989; Hioki et al., 1990; Megnekou et al., 2009; Poovassery et al., 2009; Avery et al., 2012; Sarr et al., 2012; Sharma et al.,2016

Maternal mortality Luxemburger et al., 1997; Brabin et al., 2001; Shulman et al., 2002; Nosten et al., 2004; Menéndez et al., 2008; Rogerson et al.,2018 van Zon and Eling, 1980; Oduola et al., 1982; van Zon et al., 1982; Vinayak et al., 1986; Desowitz et al., 1989; Hioki et al., 1990; Pathak et al., 1990; Pavia and Niederbuhl, 1991; Poovassery and Moore, 2006; Neres et al., 2008; Marinho et al., 2009; Megnekou et al., 2009; Poovassery et al., 2009; Rodrigues-Duarte et al., 2012; Sarr et al., 2012; Sharma and Shukla, 2014; Sharma et al.,2016

Stillbirth Menendez, 1995; Desai et al.,2007 Oduola et al., 1982; Vinayak et al., 1986; Pathak et al., 1990; Rodrigues-Duarte et al., 2012, 2018; Sharma et al.,2016

Abortion Desai et al.,2007 Poovassery and Moore, 2006, 2009; Neres et al., 2008; Poovassery et al., 2009; Silver et al., 2010; Avery et al., 2012; Sarr et al.,2012, 2015

Preterm delivery Menendez et al., 2000; Desai et al., 2007; Moore et al.,2017 van Zon et al., 1982; Neres et al.,2008

Reduced newborn/fetal weight Menendez et al., 2000; Rogerson et al., 2003; Nosten et al., 2004; Desai et al., 2007; Umbers et al.,2011 Oduola et al., 1982; Vinayak et al., 1986; Pathak et al., 1990; Neres et al., 2008; Marinho et al., 2009; Megnekou et al., 2009; Silver et al., 2010; Rodrigues-Duarte et al., 2012, 2018; Conroy et al., 2013; Barboza et al., 2014, 2017, 2019; Sharma and Shukla, 2014; Sharma et al.,2016

Congenital malaria Rai et al., 2015; Bhatia et al.,2016 Adachi et al.,2000

Placental histology

Parasite accumulation Walter et al., 1982; Beeson et al., 2002; Beeson and Brown, 2004; Muthusamy et al.,2004, 2007 Oduola et al., 1982, 1986; Vinayak et al., 1986; Desowitz et al., 1989; Pathak et al., 1990; Tegoshi et al., 1992; Poovassery and Moore, 2006, 2009; Neres et al., 2008; Marinho et al., 2009; Megnekou et al., 2009; Rodrigues-Duarte et al., 2012; Sarr et al., 2012; de Moraes et al., 2013; Lima et al., 2014; Sharma and Shukla, 2014; Sharma et al., 2016; Barboza et al.,2017

Hemozoin deposition Bulmer et al., 1993; Ismail et al.,2000 Oduola et al., 1982, 1986; Vinayak et al., 1986; Neres et al., 2008; Megnekou et al., 2009; Poovassery and Moore,2009

Immune cells infiltrate Walter et al., 1982; Ordi et al., 1998; Ismail et al., 2000; Rogerson et al., 2007; Othoro et al., 2008; Souza et al.,2013 Oduola et al., 1982, 1986; Tegoshi et al., 1992; Poovassery and Moore, 2006; Neres et al., 2008; Marinho et al., 2009; Poovassery et al., 2009; Barboza et al.,2017

Fibrin Necrosis Walter et al., 1982; Ismail et al., 2000; Souza et al.,2013 Oduola et al., 1986; Tegoshi et al., 1992; Neres et al., 2008; Poovassery et al., 2009; Avery et al., 2012; Rodrigues-Duarte et al.,2012

Syncytial knots Trophoblast rupture Ismail et al., 2000; Crocker et al., 2004; Souza et al.,2013

Trophoblast membrane thickening Ismail et al., 2000; Souza et al.,2013 Oduola et al., 1982, 1986; Tegoshi et al., 1992; Neres et al., 2008; Marinho et al., 2009; Rodrigues-Duarte et al., 2012; de Moraes et al., 2013; Barboza et al.,2014, 2017, 2019

Distinct pregnancy outcomes and placental histopathologic alterations are depicted. References used to inform this review are cited in the table according to their contribution in unraveling specific clinical and histologic manifestations of both human and murine malaria in pregnancy.