Table 3.
Top Hits From Meta-Analysis
| Metabolitea | β | CI | Unadjusted P Value | P Value | I 2 (%) |
|---|---|---|---|---|---|
| Glutamine | −0.19538 | −0.33:−0.06 | 0.004 | 0.9037087 | 0 |
| DHA.FA | 0.17259 | 0.04:0.3 | 0.0083 | 1 | 0 |
| M.HDL.PL | −0.17905 | −0.32:−0.04 | 0.0103 | 1 | 0 |
| M.HDL.P | −0.17856 | −0.32:−0.04 | 0.0104 | 1 | 0 |
| M.HDL.L | −0.17732 | −0.31:−0.04 | 0.0104 | 1 | 0 |
| FAw3.FA | 0.16222 | 0.03:0.29 | 0.0126 | 1 | 0 |
| Histidine | −0.25164 | −0.46:−0.05 | 0.0156 | 1 | 0.53 |
| M.HDL.FC | −0.15636 | −0.29:−0.02 | 0.0251 | 1 | 0 |
| M.HDL.C | −0.15174 | −0.29:−0.02 | 0.0267 | 1 | 0 |
| M.HDL.CE | −0.14723 | −0.28:−0.01 | 0.0306 | 1 | 0 |
| DHA | 0.13222 | 0:0.26 | 0.0438 | 1 | 0 |
Abbreviations: DHA, docosahexaenoic acid; DHA.FA, ratio of docosahexaenoic acid to total fatty acids; FAw3.FA, ratio of ω-3 fatty acids to total acids; HDL, high-density lipoprotein; M.HDL.C, total cholesterol in medium-sized HDL particles; M.HDL.CE, cholesterol esters in medium-sized HDL particles; M.HDL.FC, free cholesterol in medium-sized HDL particles; M.HDL.L, total lipids in medium-sized HDL particles; M.HDL.P, concentration of medium-sized HDL particles; M.HDL.PL, phospholipids in medium-sized HDL particles.
Meta-analysis across the five cohorts of logistic regression results with single metabolite measure, sex, age BMI, smoking status, T2DM status, and fasting status as covariates. β is effect size and can be interpreted as detailed in footnote b to Table 2. P value is Bonferroni–Holm-adjusted P value. I2 is the statistic used for heterogeneity between cohorts.