Table 5.
Variables Selected by the LASSO Regression
| Cohort | Time Condition | λ | Selected Variables | P Value | Significance |
|---|---|---|---|---|---|
| Full data | 2 y | 6.06 | M.VLDL.FC_, UnSat, SFA.FA | 0.175 | |
| Full data | 5 y | 28.3 | S.VLDL.FC_, Gln | 0.0114 | P < 0.05 |
| Full data | Max(t) | 2.02 | XL.VLDL.TG, XL.HDL.TG, M.HDL.PL, XXL.VLDL.PL_., XXL.VLDL.CE_, L.VLDL.PL_, L.VLDL.FC_, M.LDL.TG_, XL.HDL.CE_, XL.HDL.FC_, L.HDL.FC_, FreeC, SMs, LA, DHA.FA, LA.FA, Glc, Cit, Ala, Gln, His, Val, Phe, AcAce, bOHBut, Crea | 0.102 | |
The results of the cross-validated LASSO-penalized logistic regression for the full dataset are shown. For each regression the penalty parameter (λ) and the selected covariates (separated by commas) are given. For every model where metabolites were selected, the significance of the presence of all of the selected metabolites in the model, compared with the model without presence of metabolites, is tested in a global test, and its P value is given here. Note that the P value is only for the metabolites, not for the clinical covariates.
Abbreviations: AcAce, acetoacetate; Ala, alanine; bOHBut, 3-hydroxybutyrate; Cit, citrate; Crea, creatinine; DHA.FA, ratio of docosahexaenoic acid to total fatty acids; FreeC, free cholesterol; Glc, glucose; Gln, glutamine; His, histidine; LA, linoleic acid; LA.FA, ratio of linoleic acid to total fatty acids; L.HDL.FC_, free cholesterol to total lipids ratio in large HDLs; L.VLDL.FC_, free cholesterol to total lipids ratio in large VLDLs; L.VLDL.PL_, phospholipids to total lipids ratio in large VLDLs; M.HDL.PL, phospholipids in medium-sized HDLs; M.LDL.TG_, triglycerides to total lipids ratio in medium LDLs; M.VLDL.FC_, free cholesterol to total lipids ratio in medium VLDLs; Phe, phenylalanine; SFA.FA, ratio of saturated fatty acids to total fatty acids; SM, sphingomyelin; S.VLDL.FC_, free cholesterol to total lipids ratio in small VLDLs; UnSat, estimated degree of unsaturation; Val, valine; XL.HDL.CE_, cholesterol ester to total lipids ratio in very large HDLs; XL.HDL.FC_, free cholesterol to total lipids ratio in very large HDLs; XL.HDL.TG, triglycerides in very large HDLs; XXL.VLDL.CE_, cholesterol esters to total lipids ratio in chylomicrons and extremely large VLDLs; XL.VLDL.TG, triglycerides in extra-large VLDL particles; XXL.VLDL.PL_, phospholipids to total lipids ratio in chylomicrons and extremely large VLDLs.