Table 3.
Gene expression levels of MMP, TIMP, and IL in control and degenerated cartilage endplate (mean ± SD)
| Genes | Control group (n = 10) | Degenerated samples without Modic changes (n = 8) | Degenerated samples with Modic I (n = 2) | Degenerated samples with Modic II (n = 18) | Degenerated samples with Modic III (n = 2) | F‐value (one‐way ANOVA) |
|---|---|---|---|---|---|---|
| MMP1 | 3.48 ± 4.00 | 33.34 ± 73.01 | 10.42 ± 5.10 | 3.84 ± 3.85 | 8.00 ± 5.80 | 0.66 |
| MMP3 | 24.56 ± 18.68 | 420.10 ± 901.29 | 8474.95 ± 11894.12 | 3476.32 ± 6323.95 | 225.82 ± 149.35 | 0.26 |
| MMP9 | 0.54 ± 0.46 | 1.67 ± 1.41 | 3.23 ± 2.95 | 2.60 ± 1.75 | 1.33 ± 1.20 | 0.36 |
| MMP13 | 2.15 ± 4.24 | 0.16 ± 0.23 | 1.61 ± 0.75 | 2.41 ± 4.27 | 2.81 ± 1.06 | 0.95 |
| TIMP1 | 2.48 ± 2.92 | 0.54 ± 0.61 | 5.36 ± 4.51 | 1.04 ± 0.74 | 1.11 ± 0.37 | 0.10 |
| TIMP2 | 2.28 ± 2.34 | 1.05 ± 1.20 | 1.95 ± 0.89 | 1.31 ± 1.00 | 1.40 ± 0.25 | 0.81 |
| TIMP3 | 2.61 ± 1.99 | 12.02 ± 13.45 | 15.40 ± 17.90 | 31.16 ± 53.41 | 24.18 ± 0.72 | 0.73 |
| IL‐1α | 0.97 ± 0.60 | 2.70 ± 1.19 | 11.38 ± 10.86 | 42.18 ± 100.92 | 8.65 ± 10.70 | 0.75 |
| IL‐1β | 4.53 ± 5.60 | 61.59 ± 55.27 | 385.22 ± 533.40 | 798.02 ± 2294.12 | 1251.88 ± 1645.36 | 0.73 |
| IL‐6 | 142.99 ± 151.10 | 16.89 ± 11.24 | 325.11 ± 91.73 | 17.85 ± 21.35 | 6.36 ± 2.27 | 0.00 |