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. 2019 Jun 26;14(6):e0214779. doi: 10.1371/journal.pone.0214779

Table 3. Factors associated with inappropriate use of antibiotics on bivariate analysis.

Characteristic Appropriate use Inappropriate use, n (%) Crude OR
(95% CI)
Total
N (%)
Frequency (%) Combined use Escalated use of extended spectrum Incorrect spectrum Unnecessary use
Total 4,966 (8.7) 4,463 (7.8) 1,071 (1.9) 2,436 (4.3) 44,073 (77.3) 57,009
Physician characteristics
    Sex
Female 2376 (10.6) 1,565 (7.0) 482 (2.1) 1184 (5.3) 16,821 (75.0) Ref 22,428 (39.3)
Male 2590 (7.5) 2,898 (8.4) 589 (1.7) 1252 (3.6) 27,252 (78.8) 1.46 (1.38, 1.55) 34,581 (60.7)
    Age group (years)
25–31 1925 (8.8) 1,779 (8.1) 506 (2.3) 779 (3.5) 16,995 (77.3) Ref 21,984 (38.6)
32–38 1345 (7.4) 1,466 (8.1) 353 (2) 660 (3.6) 14,266 (78.9) 1.19 (1.11, 1.29) 18,090 (31.7)
39–75 1696 (10.0) 1,218 (7.2) 212 (1.3) 997 (5.9) 12,812 (75.7) 0.86 (0.8, 0.92) 16,935 (29.7)
    Education
College 2082 (9.9) 1,676 (7.9) 564 (2.7) 716 (3.4) 16,064 (76.1) Ref 21,102 (37.0)
Junior college 2278 (8.5) 1,923 (7.2) 356 (1.3) 1405 (5.2) 20,812 (77.7) 1.18 1.11, 1.25) 26,774 (47.0)
Technical secondary school 606 (6.6) 864 (9.5) 151 (1.7) 315 (3.4) 7,197 (78.8) 1.54 (1.40, 1.69) 9,133 (16.0)
    Work duration (years)
≤5 1485 (9.5) 1,373 (8.8) 242 (1.5) 488 (3.1) 12,098 (77.1) Ref 15,686 (27.5)
6–10 1624 (9.6) 812 (4.8) 533 (3.2) 660 (3.9) 13,285 (78.5) 0.98 (0.91, 1.06) 16,914 (30.0)
11–20 924 (6.3) 1,435 (9.7) 194 (1.3) 606 (4.1) 11615 (78.6) 1.57 (1.44, 1.71) 14,774 (25.9)
21–30 411 (6.7) 547 (9.0) 73 (1.2) 518 (8.5) 4548 (74.6) 1.45 (1.29, 1.62) 6,097 (10.7)
≥31 522 (14.8) 296 (8.4) 29 (0.8) 164 (4.6) 2,527 (71.4) 0.60 (0.54, 0.67) 3,538 (6.2)
    Professional title
Resident physician 4,001 (8.7) 3,523 (7.7) 845 (1.8) 1757 (3.8) 35,623 (77.9) Ref 45,749 (80.2)
Attending physician 830 (9.4) 881 (9.9) 218 (2.5) 584 (6.6) 6,349 (71.6) 0.93 (0.86, 1.00) 8,862 (15.5)
Associate chief physician 135 (5.6) 59 (2.5) 8 (0.3) 95 (4) 2,101 (87.6) 1.61 (1.35, 1.93) 2,398 (4.3)
Patient characteristics
    Sex
Female 2,604 (8.5) 2,454 (8.0) 703 (2.3) 1395 (4.5) 23,579 (76.7) Ref 30,735 (53.9)
Male 2,362 (9.0) 2,009 (7.6) 368 (1.4) 1041 (4) 20,494 (78.0) 0.94 (0.88, 0.99) 26,274 (46.1)
    Age group (years)
≤5 947 (10.6) 675 (7.5) 41 (0.5) 416 (4.6) 6,881 (76.8) Ref 8,960 (15.7)
5–17 1,234 (12.8) 765 (7.9) 88 (0.9) 274 (2.8) 7,271 (75.5) 0.80 0.73, 0.88) 9,632 (16.8)
18–49 1,472 (7.7) 1,222 (6.4) 501 (2.6) 916 (4.8) 14,962 (78.4) 1.41 (1.30, 1.54) 19,073 (33.5)
50–64 706 (6.5) 966 (8.9) 263 (2.4) 473 (4.4) 8,404 (77.7) 1.69 (1.53, 1.88) 10,812 (19.0)
≥65 607 (7.1) 835 (9.8) 178 (2.1) 357 (4.2) 6,555 (76.8) 1.54 (1.39 1.72) 8,532 (15.0)
Antibiotic route
Injection 911 (5.6) 1,796 (11.0) 749 (4.6) 393 (2.4) 12,492 (76.4) Ref 16,341 (28.7)
Oral 4,055 (10.0) 2,667 (6.6) 322 (0.8) 2043 (5) 31,581 (77.7) 0.53 (0.49, 0.57) 40,668 (71.3)
Payment source
Out-of-pocket 614 (10.2) 487 (8.1) 132 (2.2) 404 (6.7) 4,410 (72.9) Ref 6,047 (10.6)
New rural cooperative- medical care system 4,352 (8.5) 3,976 (7.8) 939 (1.8) 2032 (4) 39,663 (77.8) 1.21 (1.11, 1.32) 50,962 (89.4)

OR: Odds ratio, CI: Confidence interval, Ref: Reference group