Fig 2. TZs derived from the modularity analysis in Patient IL.

A Modular structure when setting EZs to inoperable zones (a resolution parameter: 1.25). The brain network is divided into seven modules and the EZ sub-module (green module) is subdivided into four sub-modules, so that each EZ (nodes 61 and 64, large circles) and its neighboring nodes belong to the same sub-module. Based on this modular structure, three nodes (black triangles) and eight edges (gray dotted lines) are derived as target nodes and target edges respectively. For the visualization, only the edges with a connection weight greater than 0.08 are drawn. B Anatomical locations and lists of the acquired TZs. Red nodes represent EZs, yellow nodes and green edges indicate target nodes and target edges. C Modular structure when adding the critical node (gray triangle) to inoperable zone in modularity analysis (a resolution parameter: 1.25). The brain network is divided into eight modules and the EZ sub-module (green module) is subdivided into two sub-modules, so that each inoperable zone and its neighboring nodes belong to the same sub-module. Based on this modular structure, three nodes (black triangles) and five edges (gray dotted lines) are derived as new target nodes and target edges respectively. D Anatomical locations and list of the newly obtained TZs. Red nodes represent EZs, yellow nodes and green edges indicate target nodes and target edges.