Fig 5. Safety evaluation results for the initial TZs and the new TZs obtained by the feedback.

The histogram shows the mean value of the similarity coefficients between the responsive activation patterns due to stimulation in all brain regions, before and after removal of the target nodes and target edges, respectively. While the elimination of initial TZs has a value lower than threshold (0.75) when stimulation is applied to node 10 to reproduce memory network (M), the removal of new TZs has values higher than the threshold in all stimulation sites.