Table 3. iMCD cases stratified based on detection of transcripts from the Herpesviridae family.
| Herpesviridae family member: | Positive | Negative |
|---|---|---|
| Number of samples | 5 | 6 |
| CRP (mg/L) | 221.5 (n = 2) | 66.9 ± 70.5 (n = 4) |
| ESR (mm/hr) | 94 (n = 2) | 73.5 ± 41.3 (n = 4) |
| Histopathology | HV 2, M 1, PC 2 | HV 1, M 1, PC 4 |
| TAFRO | 3/5 | 0/6 |
| Relapsing disease | 4/5 | 0/6 |
| Clinical response to anti-IL-6 therapy | 1/2 | 2/2 |
Clinical characteristics are presented for all iMCD patients analyzed by VirCapSeq-VERT, stratified by detection of Herpesviridae family member viral transcripts. Histopathology refers to Castleman disease histopathology subtype. PC, plasmacytic; HV, hyaline vascular; M, mixed PC and HV; TAFRO, thrombocytopenia, anasarca, fever, reticulin myelofibrosis/renal dysfunction, organomegaly; CRP, C-reactive protein; ESR, erythrocyte sedimentation rate. Values are presented as mean ± standard deviation, as appropriate.