Fig 1. Multi-CLR KO mice are dramatically susceptible to C. albicans infection.

(A-B) Survival curves based on humane end point of WT and multi-CLR KO mice infected intravenously with 5x10⁴ CFU (A) or 1.5x10⁵ CFU (B) C. albicans SC5314. Graphs show cumulative data from 7 (A) or 6 (B) independent experiments. The total number of mice and p values for survival curves of CLR KO mice compared to WT mice by log-rank test are shown in the tables opposite each graph. (C-D) Quantification of fungal burden in the kidneys (left) or brains (right) of WT and multi-CLR KO mice 7 days (C) or 6 days (D) after intravenous infection with 1.5x10⁴ CFU C. albicans. Graphs display cumulative data from 3 (C) or 2 (D) independent experiments. Each symbol represents one mouse. Two Mincle-Dectin-2-Dectin-1 TKO1 mice had to be taken on day 6 post-infection (C). The symbols for these two mice have a black outline. (Kruskal-Wallis test with Dunn’s post-test on transformed data). (E) Photograph of representative kidneys from WT and multi-CLR KO mice 6 days after intravenous infection with 1.5x10⁴ CFU C. albicans.