Figure 1.

Distribution of GFP+ ganglion cells and their axons in pigmented Cdh3-GFP mice from near birth to maturity. Photomicrographs show the termination of GFP+ axons within five separate retinorecipient nuclei of the brainstem and thalamus at three postnatal ages. Representative data are shown among P3 (n =2), P23 (n = 2) and P30 (n = 4). These are of retinal origin because they disappear after enucleation (n = 3 mice; data not shown). Note that sparse, localized retinogeniculate innervation persists in juvenile mice (P30; inset shows a high magnification view of these terminals). Drawings below show the distribution of GFP-positive retinal ganglion cells in these mice shortly after birth (left) and at maturity (right). Only GFP cells in the ganglion-cell layer are plotted; the brightly labeled amacrine cells have been excluded.