TABLE 3.

The crude and adjusted regression coefficient (β) and 95% confidence interval (CI) for final hearing threshold, absolute and relative hearing gain in relation to TBIL and DBIL stratified by initial hearing threshold

	≤70 dB HL (104 Ears)		>70 dB HL (76 Ears)
Outcomes	β (95% CI)	p	β (95%CI)	p	p Interaction
Final hearing
TBIL (per 1 μmol/L)
Crude	−0.2 (−1.1, 0.6)	0.5517	−1.9 (−3.6, −0.2)	0.026	0.0601
Adjusted*	0.2 (−0.3, 0.7)	0.4265	−1.5 (−2.7, −0.2)	0.0258	0.0141
DBIL (per 1 μmol/L)
Crude	−0.4 (−3.4, 2.5)	0.7735	−2.0 (−7.9, 3.9)	0.5118	0.6593
Adjusted*	1.4 (−0.7, 3.5)	0.1945	−2.1 (−6.1, 2.0)	0.3171	0.1000
Absolute hearing gain
TBIL (per 1 μmol/L)
Crude	−0.2 (−0.7, 0.3)	0.4172	1.2 (−0.3, 2.7)	0.1267	0.0561
Adjusted*	−0.2 (−0.7, 0.3)	0.4226	1.4 (0.2, 2.7)	0.0263	0.0144
DBIL (per 1 μmol/L)
Crude	−1.3 (−3.1, 0.5)	0.1576	1.8 (−2.4, 5.9)	0.4022	0.1632
Adjusted*	−1.4 (−3.5, 0.6)	0.1732	2.0 (−2.0, 6.0)	0.3364	0.1027
Relative hearing gain
TBIL (per 1 μmol/L)
Crude	−0.1 (−1.2, 0.9)	0.8041	1.3 (−0.3, 2.9)	0.1079	0.0783
Adjusted*	−0.2 (−1.1, 0.6)	0.6015	1.6 (0.2, 3.1)	0.024	0.0149
DBIL (per 1 μmol/L)
Crude	−1.4 (−5.0, 2.3)	0.4564	2.2 (−2.5, 6.8)	0.3597	0.2313
Adjusted*	−1.7 (−5.0, 1.6)	0.317	2.8 (−1.5, 7.1)	0.2021	0.0782

^*Adjusted for age, sex, time duration, audiogram, alcohol use, diabetes, preceding infection, magnesium, hematocrit, alkaline phosphatase, low-density lipoprotein cholesterol, neutrophil, and platelet.

DBIL indicates direct bilirubin levels; TBIL, total bilirubin levels.