Figure 1.

The restricted cubic spline for the associations of plasma metals with incident ischemic stroke. The restricted cubic spline for the associations of plasma copper (A), molybdenum (B), selenium (C), and titanium (D) with ischemic stroke. The bars represent histograms of plasma metal distribution among the total population. The lines represent adjusted odds ratios for the log-transformed levels of plasma metals in the conditional regression model. Knots were placed at the 20th, 40th, 60th, and 80th percentiles of the plasma metal distribution, and the reference value was set at the percentile of 10th. Models were adjusted for body mass index (kg/m²), smoking status (current, former, never), drinking status (current, former, never), regular exercise, family history of stroke, hyperlipidemia, diabetes mellitus, and hypertension.