Table 2. Cmax and AUC ratio of TCE, TCA and TCOH in drinking water exposure/ oil gavage exposure.
Results from a Bayesian population PBPK model based on the given experimental design and MCMC simulation. The maximum concentration (Cmax) and area under the curve (AUC) after 12 weeks of recovery (total exposure for entire experiment) are expressed as a ratio of the predicted concentrations after drinking water exposure divided by the concentrations after gavage exposure. Ratios less than one show concentrations are greater after gavage exposure, ratios greater than one show concentrations are greater after drinking water exposure.
| Parameter | Chemicals | Ratio drinking water/ oil gavage (median (5%, 95%)) |
|---|---|---|
| Cmax | Blood TCE | 0.53 (1.73, 0.33) |
| Blood TCOH | 1.12 (1.04, 1.21) | |
| Blood TCA | 1.2 (1.3, 1.1) | |
| Plasma TCA | 1.18 (1.25, 1.12) | |
| AUC 12 weeks after exposure |
Art.blood TCE | 0.502 (0.24, 0.83) |
| Blood TCOH | 2.28 (0.83, 6.36) | |
| Plasma TCA | 2.39 (1.19, 5.4) | |
| Plasma TCAfree | 2.35 (1.26, 4.98) |