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. 2019 Jun 11;11(11):3832–3850. doi: 10.18632/aging.102020

Figure 5.

Figure 5

Time-dependent decrease of senescent-associated Angptl2 and p21 mRNA expressions in the native endothelium of the aorta post-AAV1-shAngptl2 injection. Decrease of Angptl2 (A) and p21 (B) mRNA expression post-injections (1-week, n=5-6; 2-week, n=5-7; 4-week, n=4-7; 3-month, n=6-4) in the native endothelium freshly harvested from thoracic aortas of ATX mice treated with AAV1-shSCR or AAV1-shAngptl2. Average gene expression level in shSCR group was arbitrarily set at 1. Data are mean±SEM. *: p<0.05; **: p<0.01; ***: p<0.001 vs. shSCR group, at each time point.