Table 1. Clinical and biological characteristics of CRC patients.
|
All patients (n. 81) |
Patients on stage I-III (n. 61) |
Patients on stage IV (n. 20) |
||
| Age (years) | Mean (SD) | 77.1 (4.1) | 77.1 (3.8) | 76.9 (5.2) |
| Median (IQR) | 76 (74-80) | 76 (75-80) | 78 (71.5-81.5) | |
| Gender | F | 32 (39.5%) | 27 (44.3%) | 5 (25.0%) |
| M | 49 (60.5%) | 34 (55.7%) | 15 (75.0%) | |
| Geriatric assesment | Fit | 55 (67.9%) | 40 (65.6%) | 15 (75.0%) |
| Vulnerable | 20 (24.7%) | 17 (27.9%) | 3 (15.0%) | |
| Frail | 6 (7.4%) | 4 (6.6%) | 2 (10.0%) | |
| Stage | I | 3 (3.7%) | 3 (4.9%) | |
| II | 22 (27.2%) | 22 (36.1%) | ||
| III | 36 (44.4%) | 36 (59.0%) | ||
| IV | 20 (24.7%) | 20 (100%) | ||
| Site | Right | 34 (42.0%) | 29 (47.5%) | 5 (25.0%) |
| Left | 34 (42.0%) | 25 (41.0%) | 9 (45.0%) | |
| Rectum | 13 (16.0%) | 7 (11.5%) | 6 (30.0%) | |
| Adjuvant therapy | No | 30 (37.0%) | 14 (22.9%) | 16 (80.0%) |
| Yes | 51 (63.0%) | 47 (77.1%) | 4 (20.0%) | |
| IL6 | Mean (SD) | 4.0 (2.9) | 3.2 (2.0) | 6.2 (4.0) |
| Median (IQR) | 2.8 (1.9-4.5) | 2.6 (1.9-3.9) | 4.8 (3.5-9.0) | |
| CRP | Mean (SD) | 12.2 (24.6) | 8.1 (22.1) | 25.0 (28.2) |
| Median (IQR) | 3.3 (2.9-8.9) | 2.9 (2.9-4.5) | 12.6 (4.9-34.8) | |
| Telomere length (TS) | Mean (SD) | 1.3 (0.3) | 1.3 (0.3) | 1.4 (0.4) |
| Median (IQR) | 1.4 (1.1-1.5) | 1.3 (1.1-1.5) | 1.5 (1.0-1.7) | |
| TREC/105 PBMC | Mean (SD) | 48.6 (58.0) | 46.1 (56.9) | 56.1 (62.2) |
| Median (IQR) | 26.5 (10.5-62.0) | 22.5 (11.0-58.0) | 42.0 (6.0-64.0) | |
| % CD8 recent thymic emigrant cells | Mean (SD) | 38.0 (17.3) | 38.4 (18.6) | 36.6 (13.1) |
| (CD8+CD45RA+CD31+) | Median (IQR) | 37.7 (25.0-49.2) | 37.4 (26.2-51.1) | 37.7 (23.8-42.3) |
| % CD4 recent thymic emigrant cells | Mean (SD) | 18.1 (11.8) | 19.3 (12.5) | 14.8 (9.2) |
| (CD4+CD45RA+CD31+) | Median (IQR) | 15.8 (9.0-24.1) | 16.8 (9.0-27.9) | 13.4 (9.1-19.0) |
| % CD8 activated cells | Mean (SD) | 5.4 (6.1) | 4.7 (6.1) | 7.6 (6.0) |
| (CD8+CD38+HLA-DR+) | Median (IQR) | 3.2 (2.2-5.2) | 2.7 (2.0-4.3) | 5.2 (3.1-9.8) |
| %CD8 senescent cells | Mean (SD) | 44.7 (15.7) | 42.4 (14.8) | 49.8 (16.8) |
| (CD8+CD28-CD57+) | Median (IQR) | 44.0 (34.6-53.7) | 41.2 (32.7-51.5) | 47.4 (39.6-61.8) |
| %CD4 senescent cells | Mean (SD) | 9.9 (12.5) | 10.6 (13.4) | 8.5 (10.8) |
| (CD4+CD28-CD57+) | Median (IQR) | 5.1 (1.9-12.7) | 5.3 (2.4-12.6) | 4.8 (1.2-13.0) |
| CD4/CD8 ratio | Mean (SD) | 2.3 (1.7) | 2.3 (1.7) | 2.4 (1.7) |
| Median (IQR) | 1.8 (1.2-3.0) | 1.7 (1.1-3.0) | 2.1 (1.3-2.8) |