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. 2019 Jun 13;11(11):3864–3875. doi: 10.18632/aging.102022

Table 2. Univariate Cox regression models of disease-free-survival (DFS) in 61 CRC patients on stage I-III.

no. event/total number hazard ratio 95%CI p-value
Age (years) continuous 1.0 0.8-1.1 0.6965
Gender F 8/27 1
M 7/34 0.8 0.3-2.2 0.6948
Stage I-II 5/25 1
III 10/36 1.6 0.6-4.8 0.3671
Site Right 8/29 1
Left 6/25 0.9 0.3-2.5 0.7845
Rectum 1/7 0.5 0.1-4.1 0.5218
Adjuvant therapy No 5/14 1.8 0.6-5.3 0.2833
Yes 10/47 1
Geriatric assessment Fit 11/40 1
Vuln/Frail 4/21 0.7 0.2-2.2 0.4911
IL6 <=5.31 12/54 1
>best 2/4 5.6 1.1-28.7 0.0368
CRP <=5.94 11/49 1
>best 4/10 2.2 0.7-7.0 0.1682
Telomere length (T/S) <=1.37 7/33 1
>best 6/16 1.9 0.6-5.6 0.2644
TREC/105 PBMC <=40 9/37 1
>best 6/17 1.6 0.6-4.5 0.3726
% CD8 recent thymic emigrant cells <=33.53 1/23 1
(CD8+CD45RA+CD31+) >best 12/33 8.4 1.1-64.7 0.0410
% CD4 recent thymic emigrant cells <=21.42 10/35 1.8 0.6-5.8 0.3065
(CD4+CD45RA+CD31+) >best 4/21 1
% CD8 activated cells <=6.7 11/53 1
(CD8+CD38+HLA-DR+) >best 3/5 4.1 1.1-15.0 0.0297
%CD8 senescent cells <=43.96 4/25 1
(CD8+CD28-CD57+) >best 8/17 3.5 1.0-11.6 0.0434
%CD4 senescent cells <=12.83 6/32 1
(CD4+CD28-CD57+) >best 4/9 2.4 0.7-8.6 0.1680
CD4/CD8 ratio <=0.68 4/6 7.0 2.1-23.3 0.0014
>best 10/54 1