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. 2019 Jun 10;11(11):3795–3810. doi: 10.18632/aging.102017

Figure 7.

Figure 7

Bay11-7082 mitigates KA-induced memory deficits using the Morris water maze test. (A and B) During the first 2 days of visible platform tests, the KA and Bay11-7082 treated and control APP23 mice exhibited a similar latency to escape onto the visible platform. P>0.05 by Student’s t-test. (C and D) In the hidden platform tests, KA-treated APP23 mice showed a longer latency and length to escape onto the hidden platform on the third and fourth days, which was ameliorated by the addition of Bay11-7082 on the fourth day. *P<0.05; ***P<0.001 vs the control group; ##P<0.01; ###P<0.001 vs the KA-treated group by ANOVA. (E) In the probe trial on the seventh day, the KA-treated APP23 mice traveled into the third quadrant, where the hidden platform was previously placed, significantly fewer times than the controls, which were improved by the Bay11-7082 treatment. *P<0.05 vs the control group; #P<0.05 vs the KA-treated group by ANOVA; N=6.