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. 2019 Jun 10;11(11):3785–3794. doi: 10.18632/aging.102016

Table 2. Effect of metformin on the estrous cycle of mice after 3 and 6 months of feeding.

Group Regular estrous cycle (%, n/N) Irregular cycle or cession (%, n/N)
0 month CON 100 (21/21) 0 (0/21)
MET 100 (22/22) 0 (0/22)
3 months CON 85.7 (18/21) 14.3 (3/21)
MET 85 (17/20) 15 (3/20)
6 months CON 38.5 (5/13) 61.5 (8/13)
MET 78.9 (15/19) 21.1 (4/19)