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. 2019 Jun 26;3(2):026106. doi: 10.1063/1.5091713

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© Author(s).

2473-2877/2019/3(2)/026106/10

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FIG. 4. — Immunofluorescence staining of SKOV-3 cells demonstrated that they produce their own ECM proteins over the time frame of a drug screening assay. (a) Fibronectin (green)/DAPI (blue). Fibronectin can be seen on plastic as well as between cells in the MCTS. (b) Collagen 1 (green)/DAPI (blue). Collagen 1 production was not observed on plastic but was visible around the spheroids. (c) Collagen3A1 (pink)/DAPI (blue). Some collagen 3A1 may be present on plastic but is clearly visible surrounding the spheroids in both hydrogels. Scale bars = 100 μm. Images are representative from N ≥ 2 independent experiments.