Table 3.
Secondary Meniscal Findings Indicate that Adults Who Develop Accelerated Knee Osteoarthritis (AKOA) Have More Meniscal Pathology Than Adults with Either Typical or No Knee Osteoarthritis as Early as 2 Years Before Radiographic Onset
| Variable | Visit | AKOA | Typical KOA |
No KOA | AKOA vs No KOA | KOA vs No KOA | AKOA vs KOA |
|---|---|---|---|---|---|---|---|
| n (%) | n (%) | n (%) | OR (95%CI) | OR (95%CI) | OR (95%CI) | ||
| Meniscal Damage in ≥2 regions (group-by-time interactionp<0.001) | −2 | 61 (66) | 26 (40) | 29 (30) | 3.12 (1.69, 5.76) | 1.87 (1.00, 3.53) | 1.66 (0.89, 3.13) |
| −1 | 90 (77) | 63 (51) | 35 (28) | 7.60 (4.00, 14.45) | 2.38 (1.33, 4.28) | 3.19 (1.70, 5.97) | |
| Index | 99 (93) | 67 (54) | 37 (30) | 19.87 (9.08, 43.46) | 2.71 (1.56, 4.70) | 7.34 (3.42, 15.76) | |
| 1 | 73 (91) | 61 (55) | 30 (31) | 21.25 (9.24, 48.88) | 2.88 (1.64, 5.04) | 7.39 (3.27, 16.71) | |
| 2 | 33 (92) | 47 (56) | 14 (26) | 27.03 (9.55, 76.48) | 2.90 (1.60, 5.26) | 9.32 (3.36, 25.83) | |
| Medial Meniscal Pathology (group-by-time interaction p<0.001) | −2 | 66 (72) | 36 (55) | 37 (39) | 5.89 (2.80, 12.42) | 3.25 (1.62, 6.49) | 1.81 (0.85, 3.87) |
| −1 | 93 (79) | 78 (63) | 50 (40) | 9.10 (4.15, 19.94) | 3.23 (1.65, 6.31) | 2.82 (1.29, 6.16) | |
| Index | 90 (85) | 81 (65) | 49 (40) | 12.49 (5.44, 28.71) | 3.94 (2.02, 7.66) | 3.17 (1.39, 7.25) | |
| 1 | 70 (88) | 72 (65) | 39 (40) | 12.24 (5.28, 28.38) | 4.00 (2.05, 7.80) | 3.06 (1.32, 7.08) | |
| 2 | 31 (86) | 54 (64) | 23 (43) | 8.50 (3.74, 19.33) | 3.94 (1.99, 7.80) | 2.16 (0.95, 4.88) | |
| Medial Meniscal Extrusion (group-by-time interaction p<0.001) | −2 | 18 (20) | 10 (15) | 6 (6) | 4.17 (1.46, 11.88) | 3.50 (1.15, 10.63) | 1.19 (0.52, 2.71) |
| −1 | 43 (37) | 26 (21) | 7 (6) | 11.02 (4.11, 29.57) | 3.57 (1.26, 10.12) | 3.09 (1.52, 6.30) | |
| Index | 68 (64) | 36 (29) | 6 (5) | 34.09 (11.73, 99.07) | 8.13 (2.82, 23.43) | 4.19 (2.24, 7.84) | |
| 1 | 51 (64) | 36 (33) | 3 (3) | 43.28 (13.52, 138.52) | 12.29 (3.91, 38.60) | 3.52 (1.86, 6.65) | |
| 2 | 28 (78) | 29 (35) | 2 (4) | 53.97 (14.69, 198.32) | 13.90 (4.01, 48.19) | 3.88 (1.87, 8.06) | |
| Lateral Meniscal Pathology (group p=0.002; group-by-time interaction p=0.97) | −2 | 43 (47) | 19 (29) | 20 (21) | 2.96 (1.60, 5.48) | 1.74 (0.92, 3.26) | 1.71 (0.95, 3.06) |
| −1 | 52 (44) | 40 (33) | 25 (20) | 2.99 (1.63, 5.49) | 1.85 (1.00, 3.40) | 1.62 (0.92, 2.85) | |
| Index | 54 (51) | 41 (33) | 26 (21) | 3.21 (1.76, 5.86) | 1.94 (1.07, 3.51) | 1.65 (0.95, 2.87) | |
| 1 | 37 (46) | 36 (33) | 23 (24) | 2.80 (1.54, 5.08) | 1.80 (1.00, 3.22) | 1.56 (0.90, 2.71) | |
| 2 | 19 (53) | 32 (38) | 9 (17) | 2.74 (1.48, 5.07) | 1.81 (1.01 (3.24) | 1.51 (0.85, 2.69) | |
| Lateral Meniscal Extrusion | −2 | 3 (3) | 1 (2) | 0 (0) | Model Failed to Converge (see text for more details) | ||
| −1 | 9 (8) | 4 (3) | 1 (1) | ||||
| Index | 15 (14) | 5 (4) | 1 (1) | ||||
| 1 | 10 (13) | 5 (5) | 1 (1) | ||||
| 2 | 3 (8) | 4 (5) | 0 (0) | ||||
*
No statistically significant group-by-time interaction was detected; however, there was a significant group effect. OR = odds ratio, 95%CI = 95% confidence intervals
All models adjusted for sex (matching variable) and factors related to someone having no MR images at the next annual visit (i.e., age, body mass index, injury, frequent knee pain, days with limited activity in prior month, overall global rating, and WOMAC pain).