Table 1.
Classification, distribution, and functions of 5-HTRs.
| Receptor family |
Receptor subtypes |
Distribution of receptor families | Effector Mechanism |
Cellular Response |
|||||
|---|---|---|---|---|---|---|---|---|---|
| CNS | PNS | Blood vessels |
Platelets | Smooth muscles |
GI | ||||
| 5-HTR1 | 1A/1B/1D/1E/1F | × | × | Adenylate cyclase |
↓ | ||||
| 5-HTR2 | 2A/2B/2C | × | × | × | × | × | Phospholipase C | ↑ | |
| 5-HTR3 | 3A/3B | × | × | × | Ligand-gated ion channel |
↑ | |||
| 5-HTR4 | None known | × | × | Adenylate cyclase |
↑ | ||||
| 5-HTR5 | 5A/5B | × | Adenylate cyclase |
↓ | |||||
| 5-HTR6 | None known | × | Adenylate cyclase |
↑ | |||||
| 5-HTR7 | None known | × | × | × | Adenylate cyclase |
↑ | |||
Abbreviations: CNS = Central Nervous System; PNS = Peripheral Nervous System; GI = Gastrointestinal track
A modification of Translational Neuroscience 2016;7:35–49