Table 2.

5HTR distribution in animal and human brains specific to symptom group.

5-HTR family	Symptom group(s)	Distribution and Changes
		Animal	Human
5-HTR1	Cognition	Hippocampus[139], prefrontal cortex[18]	Hippocampus[139], rostral raphe nuclei [12][80], temporal cortex[40]
	BPSD	Frontal, temporal [104][26], amygdala[80]	Unknown
5-HTR2	Cognition	Hippocampus [139], prefrontal cortex [18][80], amygdala[80]	Hippocampus[139], prefrontal cortex[48]
	BPSD	Frontal[105], temporal[80], cingulate, hippocampus, amygdala[80]	Prefrontal[79][102], bed nucleus of stria termalis[78], amygdala[78], hippocampus[78], nucleus accumbens[102][105]
5-HTR3	Cognition	Prefrontal cortex[18], limbic system[139]	Hippocampus[57][139]
	BPSD	Amygdala, hippocampus[57]	Hippocampus[86], amygdala[86]
5-HTR4	Cognition	Hippocampus[43][140], prefrontal cortex[12]	Hippocampus [42], nucleus accumbens[87]
	BPSD	Frontal[44], amygdala[80], hippocampus[43]	Hippocampus[42], cerebrum[99]
5-HTR5	Cognition	Hippocampus [139], prefrontal cortex[12], amygdala[12]	Prefrontal cortex[12], amygdala[12], hypothalamus[12]
	BPSD	Unknown	Hippocampus[12], prefrontal cortex[12]
5-HTR6	Cognition	Hippocampus[139]	Prefrontal cortex[48], temporal cortex[40]
	BPSD	Hippocampus[49], dorsal raphe nucleus[49]	Neocortex[85]
5-HTR7	Cognition	Hippocampus[59], thalamus[12], raphe nuclei[141], cerebral cortex[141]	Hippocampus[12][60], raphe nuclei[141], cerebral cortex[141]
	BPSD	Hippocampus[80]	Prefrontal cortex[12], hippocampus[12]