Table 3.
Potential role of 5-HTR subtypes in behavioral and psychological symptoms of dementia.
| Receptor | Associated symptoms | Changes in Alzheimer’s disease (human studies) | Changes in Alzheimer’s disease (animal studies) |
|---|---|---|---|
| 5-HTR1A | Aggression[102], Anxiety[94], Depression [26] [62][63] [78], Delusion[94] | Raphe nuclei[62][80] | Frontal, temporal[104][26], hippocampus, amygdala |
| 5-HTR1D/1E/1F | None known | Unknown | Unknown |
| 5-HTR2A | Anxiety[79], Depression[78][79], Apathy[121], Psychosis[125] [more in comments] | Prefrontal[79], amygdala[78], hippocampus[78] | Frontal, temporal[82], cingulate, hippocampus, amygdala |
| 5-HTR2B | Aggression[102] [105] | Prefrontal[102], NAc[102] [105] | Frontal cortex[105] |
| 5-HTR2C | Anxiety[82], Depression[82], Psychosis[123] | Prefrontal[82] | BNST/Amygdala[82] [80] |
| 5-HTR3 | Anxiety[86], Psychosis[123][124] | Hippocampus[86], amygdala[86] |
Amygdala, hippocampus[57] |
| 5-HTR4 | Anxiety[87], Aggression[99], Cognition[44] | Hippocampus [42], cerebrum[99] | Frontal[44], amygdala[82] ,hippocampus[43] |
| 5-HTR5 | Hallucinations[13] | Hippocampus[13], prefrontal cortex[13] | Unknown |
| 5-HTR6 | Cognition[49] [50] [51], Anxiety[85], Depression[49] | Neocortex[85] | Hippocampus[49], dorsal raphe nucleus[49] |
| 5-HTR7 | Cognition [59] [60] | Hippocampus[60] | Hippocampus[59] [82] |
Abbreviations: NAc = Nucleus accumbens; BNST = Bed nucleus of the stria terminalis