Table 4.
Genetic studies of 5-HTRs in AD.
| Author, date | Subjects (N) | Study type | Target symptom(s) |
Association |
|---|---|---|---|---|
| Holmes, 2003[81] | AD, late-onset (158) | Association study of selected SNPs in 5-HTR2A/2C | Depression | 5-HTR2A T102C; 5-HTR2C G68C(C23S) |
| Flirski, 2011[82] | # articles dependent on foci | Systematic review | BPSD | 5-HTR2C G68C(C23S) 5-HTT LPR |
| Tang, 2017[83] | 9 eligible studies (2,005) | Meta-analysis to investigate 5HTR2A T102C polymorphism | BPSD | 5HTR2A T102C |
| Liu, 2001 [84] | AD (145) Controls (104) | Association study of 5-HTR6 polymorphism C267T | Depression | 5-HTR6 C267T |
| Tsang, 2003[85] | AD, no anxiety (22) AD, anxiety (12) Aged Controls (n=14) |
Association study | Antemortem anxiety | 5-HTT LPR |
| Engelborghs, 2013[97] |
Probable AD (249) | Prospective, longitudinal study for candidate genes | BPSD | 5-HTT LPR (SLC6A4), TPH2 |
| Ueki, 2007[100] | Mild AD (200) (160 reached moderate AD) |
Association study | BPSD | 5-HTT LPR, 5-HTTVNTR ApoE |
| Sukonick, 2001[101] | AD+Aggression (58) AD+No Aggression (79) | Case-control study | Aggression | 5-HTT LPR |
| Bevilacqua, 2010[105] |
Impulsive Males, unrelated (96) | Association study in Finnish founder population | Impulsivity | 5-HTR2B stop codon (5HTR2B Q20*) (exon-centric sequencing) |
| Montalvo-Ortiz, 2018[106] |
AAs (3,269) EAs (2,546) AAs, from GTP (89) |
GWAS | Cannabis-related aggression |
HTR2B*rs17440378 |
| Hollingworth, 2012[136] |
AD+Psychosis (1,299) AD+No Psychosis (735) Controls (5,659) | Combined analysis of three GWASs | Psychosis | SLC2A9*rs6834555, VSNL1*rs4038131 |
| Sherva, 2014[137] | AD, discovery sample (303)1 AD, replication sample (323)2 |
GWAS | Cognitive decline | SP0N1*rs110231391, SP0N1*rs116063452 |
Abbreviations: MDD = Major Depressive Disorder; GWAS=Genome-wide association study; AAs=African-Americans; EAs=European-Americans; GTP=Grady Trauma Project; ApoE= Apolipoprotein