Ablation of 4–6 week old immature neurons does not mitigate lithium response in the FST.
A) Experiment schedule to assess the role of 4–6 week old immature neurons.
B) Time immobile in the FST is reduced by lithium, and ganciclovir does not mitigate the effect of lithium.
C) Activity in the open field is unaffected by any treatment condition.
Bar graph and error bars represent mean +/− SEM; n = 7–8 per group. Individual data points are color-coded by sex (red = male, blue = female). OF, Open Field; FST, Forced Swim Test; I.P., intraperitoneal.