Sensitivity analysis—Survival model for predictors of persistent opioid users among opioid naïve patients excluding patients with hospitalizations or IBD related surgeriesa
| Predictors | Hazard ratio (95% CI) | Adjusted P-valuec |
|---|---|---|
| Depression | 1.40 (1.21–1.63) | 0.02 |
| Substance abuse | 1.42 (1.23–1.64) | 0.02 |
| Chronic obstructive pulmonary disease | 1.19 (1.05–1.35) | 0.03 |
| Crohn’s vs UC | 1.32 (1.17–1.48) | 0.02 |
| Indeterminate Colitis vs UC | 1.52 (1.24–1.86) | 0.02 |
| Subsequent flaresb | 3.75 (2.63–5.35) | 0.02 |
| Rheumatological disease | 1.26 (1.03–1.55) | 0.07 |
| 5-ASA use | 0.89 (0.80–1.00) | 0.09 |
| Anxiety | 1.13 (0.99–1.29) | 0.12 |
| Non-complicated diabetes mellitus | 1.15 (0.97–1.37) | 0.15 |
| Myocardial Infarction | 1.32 (0.91–1.91) | 0.20 |
| Other mental health disorders | 1.13 (0.93–1.37) | 0.28 |
| Gender | 1.07 (0.96–1.19) | 0.32 |
| Cerebrovascular disease | 1.13 (0.92–1.40) | 0.32 |
UC, ulcerative colitis; 5-ASA, 5-Acetylsalicylic acid.
a
Excluding patients with hospitalizations or surgeries 1–90 d following the index flare.
b
Subsequent flares were adjusted for as a time varying covariate in the survival model.
c
False discovery rate (FDR) adjusted P-value.