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. 2019 Jun 26;9:9280. doi: 10.1038/s41598-019-45643-9

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Tissue samples with metastatic tumors isolated from mice. Liver samples isolated from mice, which had inoculated melanoma cells with different levels of melanin pigmentation: non-pigmented (A,D), moderately-pigmented (B,E) and heavily-pigmented (C,F). Upper row images show entire livers, whereas lower row images show histological samples of the livers. Arrows in the upper row images indicate the locations of metastatic colonies, whereas arrow heads in the lower row images indicate individual tumors. Note the morphology of the lobules of livers in the case of mice inoculated with non-pigmented melanoma cells is much more compact than in the case of mice inoculated with pigmented cells, indicating higher tissue density. Higher tissue compaction is indicated by chevrons. Scale pitch on the rulers represents one millimeter, whereas scale bars represent 200 μm.