Table 2.
Drug resistance mutations with frequency greater than one.
| Drug | Gene | Mutation | Freq. (%) | Global freq* (%) |
|---|---|---|---|---|
| Isoniazid | katG | S315T | 63 | 4057/5423 (74.8) |
| Rifampicin | rpoB | S450L | 37 | 2968/4618 (64.3) |
| Isoniazid/Ethionamide | inhA promoter | C-15T | 35 | 872/5423 (16.1) |
| Ethambutol | embB | M306I | 15 | 564/2662 (21.2) |
| Streptomycin | rrs | A514C | 11 | 128/1408 (9.1) |
| Streptomycin | rpsL | K88R | 7 | 103/1408 (7.3) |
| Rifampicin | rpoB | H445Y | 6 | 230/4618 (5.0) |
| Isoniazid | inhA | I21V | 5 | 15/5423 (0.3) |
| Ethambutol | embB | M306V | 4 | 839/2662 (31.5) |
| Isoniazid/Ethionamide | inhA promoter | T-8C | 4 | 89/5423 (1.6) |
| Ethambutol | embB | Q497K | 3 | 20/2662 (0.8) |
| Isoniazid/Ethionamide | inhA promoter | G-17T | 3 | 72/5423 (1.3) |
| Isoniazid/Ethionamide | inhA | I21T | 3 | 32/5423 (0.6) |
| Streptomycin | gid | 102del | 3 | 12/1408 (0.9) |
| Streptomycin | gid | 351del | 3 | 6/1408 (0.4) |
| Streptomycin | rpsL | K43R | 3 | 642/1408 (45.6) |
| Ethambutol | embA | D4N | 2 | 3/2662 (0.1) |
| Ethambutol | embB | D328G | 2 | 16/2662 (0.6) |
| Ethambutol | embB | G406D | 2 | 75/2662 (2.8) |
| Isoniazid/Ethionamide | inhA | I194T | 2 | 88/5423 (1.6) |
| Pyrazinamide | pncA | D12A | 2 | 11/1946 (0.6) |
| Pyrazinamide | pncA | G24D | 2 | 3/1946 (0.2) |
| Pyrazinamide | pncA | I133T | 2 | 24/1946 (1.2) |
| Rifampicin | rpoB | 1297_1298insTTC | 2 | 11/4618 (0.2) |
| Rifampicin | rpoB | 1295_1303del | 2 | 5/4618 (0.1) |
| Rifampicin | rpoB | D435F | 2 | 23/4618 (0.5) |
| Rifampicin | rpoB | S441L | 2 | 17/4618 (0.4) |
| Streptomycin | gid | 386del | 2 | 2/1408 (0.1) |
| Streptomycin | rrs | C517T | 2 | 57/1408 (4.1) |
*Based on the 17k dataset.