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. 2019 Jun 26;10(7):503. doi: 10.1038/s41419-019-1744-5

Fig. 1. Formation of circRNAs by pre-mRNA back-splicing events.

Fig. 1

a The intron complementary repeat sequences or RNA-binding proteins such as QKI, MBL, and NF90/NF110 promote the back-splicing. b A lariat containing one or more skipped exons is re-spliced to generate a circRNA and a double lariat, and the circRNA may be an EIciRNAs or an ecircRNA. c CiRNA is generated from the intron lariat