. 2019 Jun 19;10:1358. doi: 10.3389/fimmu.2019.01358

Table 2.

Parameter estimates of the ELR-model for the inflationary M38-specific CD8⁺ T cell response.

	Acute viral load at day 7	T cell concentration at day 7	Net-replication rate of active virus	T cell mediated viral clearance rate	Infection rate of non-haem. cells	Net-replication rate of latent virus	Activation rate of T cells	Death rate of T cells
Mouse	V₇	E₇	ρ_V	k	β	ρ_R	ρ_E	δ
	(a.u. ml⁻¹)	(× 10⁴cells/ml)	(day⁻¹)	(× 10⁻⁶day⁻¹)	(× 10⁻⁴day⁻¹)	(day⁻¹)	(day⁻¹)	(day⁻¹)
1	1.73	6.16	0.15	2.95	5.39	0.414	0.295	0.323
2	1.70	3.94	0.13	3.01	4.79	0.413	0.310	0.318
3	1.79	3.58	0.09	3.12	5.16	0.414	0.289	0.326
4	1.69	3.35	0.10	3.06	4.68	0.413	0.304	0.320
5	1.73	5.58	0.11	3.04	5.15	0.413	0.290	0.324
6	1.70	2.42	0.09	3.14	5.16	0.415	0.290	0.325
7	1.71	3.08	0.18	2.86	5.10	0.414	0.298	0.322
Pop. estimate	1.72	3.60	0.11	3.00	4.90	0.414	0.296	0.322
s.e.	0.06	0.66	0.036	0.55	2.20	0.035	0.03	0.03
relative s.e. (%)	3	18	32	18	45	8	10	10

Estimates for individual parameters obtained when fitting the ELR-model to the M38-specific CD8⁺ T cell responses using a non-linear mixed effect modeling approach. Estimates for individual mice and the population based parameter estimates (Pop. estimate) including (relative) standard errors (s.e.) are shown. For a detailed description of the model system see Equation (3). (a.u. – arbitrary units).