Table 3. Mutations associated with primary spinal column malignancies (PSCM).

Tumor	Gene	Locus	Grade	Molecular finding
Chordoma	T	6q27	–	Multiple germline SNPs associated with development of familial and sporadic chordoma; rs2305089 shown to be prognostic for OS
	LYST	1q42.1-q42.2	–	Recurrent inactivating somatic mutations in sporadic chordomas
	TERT	5p15.33	–	Mutations in TERT promoter shown to have prognostic implications

OS, overall survival; SNP, single nucleotide polymorphism.