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DFO was ineffective in β-HIF-1α islet transplants. Islets for both groups were exposed to 5% oxygen for 2 h with or without DFO treatment prior to transplantation. (A) Floxed-control recipients had improved glucose values after transplantation when islets were cultured with DFO. (B) No improvement was seen for β-HIF-1α-null transplants when the islets were cultured with DFO. n = 4–6 per group. **p < 0.01 versus control-cultured islets.
