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Proposed model for Nrf2 nuclear regulation. Upon activation, newly synthesized Nrf2 is translocated to the nucleus where it presumably undergoes sumoylation. Within PML-NBs polysumoylated Nr f2 is ubiquitylated by Arkadia with K48-linked ubiquitin chains. Ubiqutylation by Arkadia marks Nrf2 for stabilization, which enales transcription.
