Table 1.

Platelet molecules that modulate neutrophil activation.

Factors stored in granules	Adhesive glycoproteins: P-selectin*(27, 40), Fibrinogen (41), vWF*(36, 42, 43), Fibronectin (44), Thrombospondin (44)
	Coagulation factors: Protein S (45), Factor XI (46)
	Mitogenic factors: PDGF (47), TGF-β (48), EGF (49)
	Angiogenic / Vasoactive factors: VEGF (50), PF4 inhibitor (51), Serotonin (52)
	Chemokines: CXCL7 (53), CXCL4*(PF4) (54, 55), CXCL1 (GROα) (56, 57), CXCL5*(58), CCL5*(RANTES) (59, 60), CCL3 (MIP1α) (61)
Unknown location	CCL7(MCP3) (56), IL1β (62), HMGB1*(63), Defensins*(11)
Plasma Membrane	Thromboxane A2* (36), PAF (64), CD40L (9), TREM-1 ligand (65), αIIbβb3 Integrin*(66, 67), GPIb*(36), ICAM2 (68), P-selectin*(35)

vWF, von Willebrand factor; PDGF, platelet derived growth factor; TGF-β, transforming growth factor β; VEGF, vascular endothelial growth factor; PF4, Platelet Factor 4; IL1β, interleukin 1β; HMGB1, high mobility group box protein 1; PAF, platelet activating factor; TREM-1, triggering receptor expressed on myeloid cells 1; GPIb, glycoprotein Ib; ICAM2, intercellular adhesion molecule 2. Factors known to be associated with NET production by neutrophils are denoted with an*.