Table 3.

Fluconazole steady‐state pharmacokinetics (400 mg day^–1) in healthy volunteers

Parametera	Fluconazole
C0 (mg L−1)	17.3 (15.9–18.9)
Cmax (mg L−1)	26.2 (24.1–28.4)
AUC(0–24) (h mg L−1)	493 (454–536)
tmax (h)	3.0 (2.0–6.0)
CL/F (L h−1)	0.81 (0.75–0.88)
V/F (L)	46.7 (38.9–56.0)
t1/2 (h)	39.9 (33.5–47.4)

All values are reported as geometric mean and 90% confidence interval, except t_max, which is reported as median and range.

AUC, area under the curve; C₀, predose concentration; CL/F, apparent clearance after oral administration; C_max, maximum concentration; t_1/2, half‐life; t_max, time of maximum concentration; V/F, apparent terminal volume of distribution after oral administration.

^a n = 11, after exclusion of 1 participant who skipped some fluconazole doses after the 6^th fluconazole day.