Table 2.

Predictors of log‐transformed thiopurine metabolites (mean ± standard deviation)

Variables	rsID	Maj	Min	Genotype					Dominant				Recessive
				Maj hom	Het	Min hom	P	FDR P	Maj hom + het	Min hom	P	FDR P	Maj hom	Het + min hom	P	FDR P
6‐TGN
ATIC	rs16853834	C	T	2.56 ± 0.20	2.65 ± 0.22	2.59 ± 0.12	0.0903	0.9914	2.60 ± 0.21	2.59 ± 0.12	0.9149	0.9553	2.56 ± 0.20	2.64 ± 0.20	0.0415	0.9077
GART	rs2070388	G	C	2.57 ± 0.20	2.69 ± 0.19	2.51 ± 0.35	0.0090	0.3135	2.60 ± 0.20	2.51 ± 0.35	0.2263	0.9553	2.57 ± 0.20	2.65 ± 0.23	0.0351	0.9077
HIVEP2‐AIG1 a	rs200148	G	A	2.60 ± 0.20	2.41 ± 0.35		0.0194	0.5052
XDH	rs2295475	G	A	2.57 ± 0.25	2.59 ± 0.18	2.71 ± 0.19	0.0634	0.9914	2.58 ± 0.21	2.71 ± 0.19	0.0235	0.9553	2.57 ± 0.25	2.62 ± 0.18	0.2216	0.9077
NUDT15	rs116855232	C	T	2.64 ± 0.19	2.51 ± 0.15	1.95 ± 0.27	<.0001	<.0001	2.61 ± 0.19	1.95 ± 0.27	<.0001	<.0001	2.64 ± 0.19	2.46 ± 0.24	<.0001	0.0024
NUDT15	rs186364861	G	A	2.62 ± 0.19	2.39 ± 0.28		<.0001	0.0040
6‐MeMPN
ATIC	rs3821353	T	G	3.48 ± 0.67	3.76 ± 0.46	3.52 ± 0.56	0.0438	0.9027	3.62 ± 0.59	3.52 ± 0.56	0.3589	0.9666	3.48 ± 0.67	3.65 ± 0.52	0.1125	0.7348
ATIC	rs16853834	C	T	3.53 ± 0.57	3.74 ± 0.52	3.77 ± 0.46	0.0779	0.9027	3.62 ± 0.56	3.77 ± 0.46	0.3735	0.9666	3.53 ± 0.57	3.74 ± 0.51	0.0240	0.7348
FAM8A6P	rs1040637	G	A	3.64 ± 0.55	3.32 ± 0.73	3.42 ± 0.54	0.1131	0.9027	3.6 ± 0.57	3.42 ± 0.54	0.5977	0.9978	3.64 ± 0.55	3.34 ± 0.69	0.0383	0.7348
MTHFD1	rs2236225	G	A	3.51 ± 0.62	3.71 ± 0.47	3.98 ± 0.39	0.0775	0.9027	3.59 ± 0.57	3.98 ± 0.39	0.2443	0.9666	3.51 ± 0.62	3.73 ± 0.46	0.0338	0.7348
MTHFR	rs1801133	C	T	3.58 ± 0.60	3.55 ± 0.59	3.88 ± 0.33	0.1226	0.9027	3.56 ± 0.59	3.88 ± 0.33	0.0418	0.9666	3.58 ± 0.60	3.60 ± 0.57	0.8647	0.9763
NUDT15	rs147390019	G	A	3.62 ± 0.55	2.97 ± 0.94		0.0239	0.9027
NUDT15	rs186364861	G	A	3.62 ± 0.58	3.42 ± 0.43		0.2224	0.9027
TPMT		*1	Other	3.62 ± 0.55	3.05 ± 0.69		0.0156	0.9027
6‐MeMPN/6‐TGN ratio
ABCC4	rs2274407	C	A	0.98 ± 0.58	1.08 ± 0.49	−0.09 ± 0.00	0.0932	0.9573	1.01 ± 0.55	−0.09 ± 0.00	0.0481	0.9388	0.98 ± 0.58	1.05 ± 0.51	0.5103	0.9371
ATIC	rs3821353	T	G	0.88 ± 0.72	1.18 ± 0.43	0.92 ± 0.57	0.0329	0.9573	1.03 ± 0.61	0.92 ± 0.57	0.3294	0.9388	0.88 ± 0.72	1.06 ± 0.51	0.1006	0.9371
FAM8A6P	rs1040637	G	A	1.04 ± 0.55	0.74 ± 0.78	0.75 ± 0.77	0.1339	0.9573	1.01 ± 0.58	0.75 ± 0.77	0.4579	0.9550	1.04 ± 0.55	0.74 ± 0.75	0.0446	0.9371
GNG2	rs12886319	T	C	1.14 ± 0.50	0.89 ± 0.65	1.10 ± 0.43	0.0507	0.9573	0.99 ± 0.61	1.10 ± 0.43	0.4289	0.9550	1.14 ± 0.50	0.93 ± 0.61	0.0481	0.9371
MTHFD1	rs2236225	G	A	0.91 ± 0.66	1.10 ± 0.41	1.41 ± 0.28	0.0905	0.9573	0.98 ± 0.58	1.41 ± 0.28	0.2080	0.9388	0.91 ± 0.66	1.12 ± 0.41	0.0457	0.9371
NUDT15	rs147390019	G	A	1.02 ± 0.56	0.37 ± 1.17		0.0269	0.9573
NUDT15	rs186364861	G	A	1.00 ± 0.60	1.03 ± 0.39		0.0269	0.9864
TPMT		*1	Other	1.03 ± 0.57	0.39 ± 0.50		0.0085	0.8871

Abbreviations: FDR, false‐discovery rate; Het, heterozygote; Maj: major allele; Maj hom, major allele homozygote; Min hom, minor allele homozygote; Min, minor allele.

P‐values < 0.05 calculated by linear regression analysis are shown in bold.

^aIntronic SNP between theAIG1 and HIVEP2 gene.