Table 3.

Predictors of log‐transformed 6‐TGN/6‐MP dose ratio (mean ± standard deviation)

Genes	rsID	Maj	Min	Total number of patients			Genotype					Dominant				Recessive
				Maj hom	Het	Min hom	Maj hom	Het	Min hom	P	FDR P	Maj hom + het	Min hom	P	FDR P	Maj hom	Het + min hom	P	FDR P
ABCC4	rs2274407	C	A	89	42	1	1.14 ± 0.28	1.12 ± 0.21	1.79	0.0406	0.8253	1.13 ± 0.26	1.79	0.0124	0.5312	1.14 ± 0.28	1.14 ± 0.23	0.9277	0.9873
AHCY	rs819146	T	G	78	39	9	1.18 ± 0.26	1.06 ± 0.27	1.06 ± 0.23	0.0484	0.8253	1.14 ± 0.27	1.06 ± 0.23	0.3666	0.9941	1.18 ± 0.26	1.06 ± 0.26	0.0137	0.6891
GART	rs2070388	G	C	93	35	9	1.11 ± 0.23	1.24 ± 0.31	1.05 ± 0.32	0.0369	0.8253	1.15 ± 0.26	1.05 ± 0.32	0.2739	0.9941	1.11 ± 0.23	1.20 ± 0.32	0.0878	0.7726
NUDT15	rs116855232	C	T	109	27	3	1.15 ± 0.24	1.14 ± 0.30	0.55 ± 0.24	0.0003	0.0335	1.15 ± 0.25	0.55 ± 0.24	<.0001	0.0052	1.15 ± 0.24	1.08 ± 0.34	0.1959	0.8077
PACSIN2	rs2413739	C	T	116	13		1.12 ± 0.26	1.28 ± 0.32		0.0386	0.8253
TPMT		*1	Other	133	6		1.12 ± 0.25	1.47 ± 0.37		0.0016	0.0847
TYMS	rs34743033	≥3 R	2 R	91	45	3	1.18 ± 0.28	1.07 ± 0.21	1.07 ± 0.09	0.0556	0.8253	1.14 ± 0.27	1.07 ± 0.09	0.6575	0.9941	1.18 ± 0.28	1.07 ± 0.20	0.0160	0.6891

Abbreviations: FDR, false‐discovery rate; Het, heterozygote; Hom, homozygote; Maj, major allele; Min, minor allele; R, repeats.

P‐values < 0.05 calculated by linear regression analysis are shown in bold.