Table 2.
The list of mutations of six recurrently mutated genes, mutation position, number of patients affected, corresponding patient HLA allele, number of predicted neoantigens, and number of patients affected in ICGC project.
| Gene | Mutation in Protein Position | Number of patients affected in this study (total 32) | Patient HLA Allele | Number of predicted neoantigens | Number of patients affected in ICGC (total 12,198) |
|---|---|---|---|---|---|
| BRCA2 | I27V | 1 | B58:01 C03:02 C08:01 |
6 | 0 |
| S37L | 1 | B15:02 B58:01 C03:02 |
6 | 1 | |
| V144F | 1 | B15:02 C03:02 |
5 | 0 | |
| Q147R | 1 | A33:03 | 2 | 0 | |
| D156E | 1 | A11:01 | 1 | 0 | |
| N289H | 1 | A02:01 C03:02 |
5 | 3 | |
| T2542M | 1 | C14:02 | 2 | 0 | |
|
| |||||
| FAT4 | Q453L | 1 | A02:01 C03:02 |
12 | 5 |
| V462E | 1 | B40:01 B58:01 C03:02 |
11 | 0 | |
| D598Y | 1 | A02:01 B15:01 |
5 | 0 | |
| A807V | 1 | A02:01 B40:01 B58:01 C03:02 |
13 | 6 | |
|
| |||||
| GNAQ | D95Y | 1 | A24:10 B18:02 B39:01 C07:02 |
8 | 0 |
| T96S | 3 | A02:01 A03:01 A11:01 B15:01 B39:01 |
25 | 10 | |
|
| |||||
| LRP1B | H4368Q | 1 | A11:02 | 1 | 0 |
| L1995M | 1 | C03:04 | 1 | 0 | |
| R3026S | 1 | A03:01 B15:01 |
3 | 0 | |
| R4062K | 1 | A11:01 A33:03 C03:02 |
8 | 0 | |
| T2206I | 1 | A02:01 | 1 | 0 | |
|
| |||||
| PIK3CA | G106C | 1 | A03:01 A11:01 |
2 | 0 |
| H1047Y | 1 | B15:01 | 1 | 8 | |
| V344M | 1 | A03:01 A11:01 C14:02 |
4 | 5 | |
|
| |||||
| PREX2 | E1428K | 1 | A30:01 | 2 | 0 |
| H895Q | 1 | B15:01 C03:03 |
3 | 0 | |
| Q102H | 1 | B15:01 | 1 | 0 | |
| S1488L | 1 | A02:01 A33:03 B40:01 C07:02 |
10 | 0 | |