Table 1.
Clinicopathological characteristics by tumor location.
| Total GC | PGC | DGC | P Value | |
|---|---|---|---|---|
| N (%) | N (%) | N (%) | ||
| Age at diagnosis (years) | ||||
| Mean (SD) | 58.5 (11.4) | 61.5 (10.0) | 56.4 (11.9) | <0.001 |
| Younger (≤35) | 590 (3.7) | 86 (1.3) | 504 (5.2) | |
| Middle-aged (36-65) | 10,842 (67.3) | 4,026 (62.1) | 6,816 (70.7) | |
| Older (≥66) | 4,685 (29.1) | 2,366 (36.5) | 2,319 (24.1) | <0.001 |
| Gender | ||||
| Male | 4,171 (25.9) | 5,374 (82.9) | 6,574 (68.2) | |
| Female | 11,948 (74.1) | 1,105 (17.1) | 3,066 (31.8) | <0.001 |
| Smoking status | ||||
| Never smokers | 9,289 (57.6) | 3,065 (47.3) | 6,224 (64.6) | |
| Smokers | 6,621 (41.1) | 3,352 (51.7) | 3,269 (33.9) | <0.001 |
| Current smokers | 4,634 (28.8) | 2,210 (34.1) | 2,424 (25.2) | |
| Ex-smokers | 1,987 (12.3) | 1,142 (17.6) | 845 (8.8) | <0.001 |
| Alcohol consumption | ||||
| Never drinkers | 10,398 (64.5) | 3,716 (57.4) | 6,682 (69.3) | |
| Drinkers | 5,496 (34.1) | 2,699 (41.7) | 2,797 (29.0) | <0.001 |
| Current drinkers | 4,752 (29.5) | 2,416 (37.3) | 2,336 (24.2) | |
| Ex-drinkers | 744 (4.6) | 283 (4.4) | 461 (4.8) | <0.001 |
| BMI (kg/m2) | ||||
| <18.5 | 1,066 (6.6) | 380 (5.9) | 686 (7.1) | |
| 18.5-22.9 | 6,097 (37.8) | 2,301 (35.5) | 3,796 (39.4) | |
| 23-27.4 | 6,576 (40.8) | 2,760 (42.6) | 3,816 (39.6) | |
| ≥27.5 | 2,028 (12.6) | 909 (14.0) | 1,119 (11.6) | <0.001 |
| H. pylori | ||||
| No | 1,247 (7.7) | 437 (6.7) | 625 (6.5) | |
| Yes | 956 (5.9) | 331 (5.1) | 810 (8.4) | |
| Unknown | 13,916 (86.3) | 5,711 (88.2) | 8,205 (85.1) | <0.001 |
| Pathologic T stage | ||||
| T0+Tis | 58 (0.4) | 14 (0.2) | 44 (0.5) | |
| T1 | 2,491 (15.5) | 596 (9.2) | 1,895 (19.7) | |
| T2 | 1,376 (8.5) | 441 (6.8) | 935 (9.7) | |
| T3 | 3,019 (18.7) | 1,640 (25.3) | 1,379 (14.3) | |
| T4 | 6,288 (39.0) | 2,573 (39.7) | 3,715 (38.5) | |
| TX | 2,887 (17.9) | 1,215 (18.8) | 1,672 (17.3) | <0.001 |
| Pathologic N stage | ||||
| N0 | 4,538 (28.2) | 1,623 (25.1) | 2,915 (30.2) | |
| N1 | 2,281 (14.1) | 983 (15.2) | 1,298 (13.5) | |
| N2 | 2,417 (15.0) | 1,081 (16.7) | 1,336 (13.9) | |
| N3 | 3,759 (23.3) | 1,489 (23.0) | 2,270 (23.6) | |
| NX | 3,124 (19.4) | 1,303 (20.1) | 1,821 (18.9) | <0.001 |
| Pathologic M stage | ||||
| M0 | 13,629 (84.6) | 5,555 (85.7) | 8,074 (83.8) | |
| M1 | 1,883 (11.7) | 651 (10.1) | 1,232 (12.8) | <0.001 |
| pTNM | ||||
| 0 | 52 (0.3) | 13 (0.2) | 39 (0.4) | |
| I | 2,989 (18.5) | 825 (12.7) | 2,164 (22.5) | |
| II | 2,112 (13.1) | 929 (14.3) | 1,183 (12.3) | |
| III | 7,354 (45.6) | 3,272 (50.5) | 4,082 (42.3) | |
| IV | 1,883 (11.7) | 651 (10.1) | 1,232 (12.8) | <0.001 |
| Lauren classification | ||||
| Intestinal | 2,390 (14.8) | 1,215 (18.8) | 1,175 (12.2) | |
| Diffuse | 2,202 (13.7) | 555 (8.6) | 1,647 (17.1) | |
| Mixed | 1,486 (9.2) | 592 (9.1) | 894 (9.3) | |
| Unknown | 10,041 (62.3) | 4,117 (63.5) | 5,924 (61.5) | <0.001 |
| Type of gastrectomy | ||||
| Gastrectomy | 13,190 (81.8) | 5,260 (81.2) | 7,930 (82.3) | |
| No surgery | 2,929 (18.2) | 1,219 (18.8) | 1,710 (17.7) | 0.068 |
| Surgical Margin | ||||
| Negative | 12,457 (77.3) | 4,950 (76.4) | 7,507 (77.9) | |
| Positive on the proximal margin | 183 (1.1) | 91 (1.4) | 92 (1.0) | |
| Positive on the distal margin | 197 (1.2) | 74 (1.1) | 123 (1.3) | |
| Positive on the proximal and distal margin | 46 (0.3) | 12 (0.2) | 34 (0.4) | 0.002 |
| HER2 score | ||||
| 0 (-) | 2,850 (17.7) | 1,037 (16.0) | 1,813 (18.8) | |
| 1 (+) | 2,620 (16.3) | 971 (15.0) | 1,649 (17.1) | |
| 2 (++) | 1,082 (6.7) | 466 (7.2) | 616 (6.4) | |
| 3 (+++) | 522 (3.2) | 275 (4.2) | 247 (2.6) | |
| Unknown | 9,045 (56.1) | 3,730 (57.6) | 5,315 (55.1) | <0.001 |
| Linitis plastica | ||||
| No | 15,670 (97.2) | 6,286 (97.0) | 9,384 (97.3) | |
| Yes | 110 (0.7) | 31 (0.5) | 79 (0.8) | 0.024 |
| Borrmann classification | ||||
| Borrmann I | 1,160 (7.2) | 714 (11.0) | 446 (4.6) | |
| Borrmann II | 4,605 (28.6) | 1,926 (29.7) | 2,679 (27.8) | |
| Borrmann III | 3,843 (23.8) | 1,574 (24.3) | 2,269 (23.5) | |
| Borrmann IV | 981 (6.1) | 347 (5.4) | 634 (6.6) | |
| Unknown | 1,807 (11.2) | 696 (10.7) | 1,111 (11.5) | <0.001 |
GC, gastric cancer; PGC, proximal gastric cancer; DGC, distal gastric cancer; SD, standard deviation.