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. 2019 Jun 13;2019:9784039. doi: 10.1155/2019/9784039

Table 2.

Univariate survival analysis by tumor location.

Prognostic Factors PGC group (N=4,716) DGC group (N=7,228) PGC versus DGC
HR 95% CI P Value HR 95% CI P Value HR 95% CI P Value
Lower Upper Lower Upper Lower Upper
Age (years)
 Younger (≤35) 1.00 1.00 2.20 1.50 3.22 <0.001
 Middle-aged (36-65) 0.47 0.33 0.65 <0.001 0.94 0.77 1.14 0.52 1.12 1.03 1.21 0.008
 Older (≥66) 0.51 0.37 0.72 <0.001 1.01 0.82 1.24 0.92 1.14 1.01 1.28 0.028
Gender
 Male 1.00 1.00 1.16 1.08 1.25 <0.001
 Female 1.04 0.91 1.19 0.55 1.07 0.98 1.17 0.12 1.13 0.98 1.30 0.097
Smoking status
 Never smoker 1.00 1.00 1.08 0.99 1.18 0.074
 Smokers 1.00 0.91 1.10 0.98 0.85 0.78 0.93 <0.001 1.27 1.15 1.41 <0.001
 Current smokers 1.03 0.92 1.14 0.63 0.89 0.81 0.99 0.023 1.25 1.11 1.40 <0.001
 Ex-smokers 0.94 0.82 1.09 0.41 0.72 0.60 0.86 <0.001 1.39 1.13 1.71 0.002
Alcohol consumption
 Never drinkers 1.00 1.00 1.11 1.03 1.21 0.009
 Drinkers 0.95 0.86 1.05 0.35 0.85 0.77 0.94 0.001 1.24 1.11 1.39 <0.001
 Current drinkers 0.97 0.87 1.07 0.55 0.90 0.82 1.00 0.048 1.19 1.06 1.34 0.004
 Ex-drinkers 0.82 0.62 1.07 0.14 0.58 0.45 0.74 <0.001 1.55 1.08 2.23 0.017
BMI (kg/m2)
 <18.5 1.24 1.02 1.51 0.033 1.12 0.96 1.32 0.16 1.33 1.06 1.68 0.016
 18.5-22.9 1.00 1.00 1.21 1.09 1.34 <0.001
 23-27.4 0.73 0.65 0.82 <0.001 0.82 0.75 0.91 <0.001 1.07 0.96 1.19 0.22
 ≥27.5 0.79 0.67 0.92 0.0024 0.73 0.63 0.85 <0.001 1.30 1.08 1.57 0.006
H. pylori
 No 1.00 1.00 1.55 1.09 2.21 0.016
 Yes 1.45 1.01 2.08 0.044 1.71 1.25 2.33 0.001 1.31 0.95 1.81 0.095
 Unknown 2.36 1.80 3.09 <0.001 3.31 2.60 4.21 <0.001 1.10 1.03 1.18 0.005
Pathologic T stage
 T0+Tis 3.28 0.79 13.58 0.10 2.58 0.94 7.08 0.066 2.46 0.45 13.53 0.30
 T1 1.00 1.00 2.07 1.39 3.10 <0.001
 T2 1.58 1.02 2.45 0.041 3.26 2.38 4.46 <0.001 0.96 0.67 1.38 0.84
 T3 3.86 2.77 5.38 <0.001 8.32 6.39 10.83 <0.001 0.92 0.80 1.06 0.26
 T4 6.69 4.83 9.28 <0.001 12.61 9.81 16.21 <0.001 1.05 0.95 1.15 0.37
 TX 11.12 7.99 15.48 <0.001 27.37 21.21 35.31 <0.001 0.81 0.72 0.92 <0.001
Pathologic N stage
 N0 1.00 1.00 1.65 1.35 2.02 <0.001
 N1 1.91 1.56 2.36 <0.001 2.39 1.96 2.90 <0.001 1.31 1.07 1.60 <0.001
 N2 2.84 2.34 3.44 <0.001 3.89 3.26 4.65 <0.001 1.20 1.01 1.41 0.034
 N3 5.00 4.20 5.95 <0.001 8.42 7.21 9.83 <0.001 0.97 0.86 1.08 0.56
 NX 6.56 5.51 7.81 <0.001 12.60 10.79 14.73 <0.001 0.85 0.76 0.96 0.007
Pathologic M stage
 M0 1.00 1.00 1.28 1.18 1.38 <0.001
 M1 4.96 4.33 5.68 <0.001 7.45 6.73 8.25 <0.001 0.85 0.73 0.98 0.027
pTNM
 0 4.06 0.99 16.71 0.052 2.25 0.71 7.14 0.17 3.16 0.53 19.05 0.21
 I 1.00 1.00 2.04 1.42 2.94 <0.001
 II 2.26 1.63 3.15 <0.001 4.43 3.35 5.86 <0.001 1.03 0.81 1.29 0.84
 III 6.39 4.79 8.52 <0.001 12.28 9.64 15.64 <0.001 1.03 0.94 1.12 0.58
 IV 23.33 17.19 31.68 <0.001 54.77 42.63 70.38 <0.001 0.85 0.73 0.98 0.027
Lauren classification
 Intestinal 1.00 1.00 1.68 1.31 2.15 <0.001
 Diffuse 1.93 1.54 2.42 <0.001 2.09 1.66 2.62 <0.001 1.54 1.25 1.90 <0.001
 Mixed 1.54 1.22 1.94 0.0003 1.37 1.04 1.81 0.024 1.88 1.45 2.46 <0.001
 Unknown 2.76 2.35 3.24 <0.001 4.45 3.64 5.44 <0.001 1.05 0.97 1.13 0.22
Stage
 Early stage 1.00 1.00 2.09 1.31 3.32 0.002
 LAGC 5.29 3.65 7.65 <0.001 9.18 7.24 13.04 <0.001 1.09 1.01 1.19 0.032
 Distant 25.33 17.25 37.20 <0.001 60.25 44.52 81.52 <0.001 0.85 0.73 0.98 0.027
Type of gastrectomy
 Gastrectomy 1.00 1.00 1.24 1.15 1.34 <0.001
 No surgery 3.01 2.71 3.35 <0.001 4.47 4.08 4.88 <0.001 0.84 0.74 0.94 0.002
Surgical Margin
 Negative 1.00 1.00 1.27 1.17 1.38 <0.001
 Positive on the proximal margin 1.96 1.34 2.87 0.0006 2.98 2.07 4.28 <0.001 0.81 0.48 1.37 0.43
 Positive on the distal margin 2.49 1.63 3.79 <0.001 2.56 1.85 3.53 <0.001 1.25 0.74 2.12 0.40
 Positive on the proximal and distal margin 1.08 0.27 4.34 0.91 2.57 1.33 4.95 0.005 0.60 0.13 2.80 0.51
HER2 score
 0 (-) 1.00 1.00 1.45 1.22 1.73 <0.001
 1 (+) 0.70 0.57 0.86 0.001 0.85 0.72 1.02 0.073 1.19 0.98 1.46 0.083
 2 (++) 0.69 0.53 0.89 0.005 0.66 0.51 0.85 0.002 1.54 1.11 2.12 0.01
 3 (+++) 0.94 0.71 1.26 0.68 0.99 0.72 1.38 0.96 1.38 0.93 2.07 0.11
 Unknown 1.72 1.49 1.98 <0.001 2.44 2.15 2.77 <0.001 1.03 0.95 1.11 0.49
Linitis plastica
 No 1.00 1.00 1.15 1.08 1.23 <0.001
 Yes 2.44 1.44 4.12 0.001 2.37 1.63 3.44 <0.001 1.22 0.64 2.33 0.54
Borrmann classification
 Borrmann I 1.00 1.00 1.03 0.78 1.35 0.85
 Borrmann II 1.03 0.85 1.24 0.79 0.93 0.73 1.17 0.52 1.14 1.00 1.30 0.045
 Borrmann III 1.14 0.94 1.38 0.20 1.13 0.90 1.43 0.30 1.03 0.90 1.17 0.71
 Borrmann IV 2.16 1.70 2.75 <0.001 2.11 1.63 2.73 <0.001 1.05 0.84 1.31 0.67
 Unknown 2.44 1.99 3.01 <0.001 3.09 2.44 3.93 <0.001 0.81 0.69 0.94 0.007
Location
 PGC 1.00
 DGC 0.87 0.82 0.93 <0.001