Figure 4.

UCA1 Functions as a Molecular Sponge of miR-143 in Ovarian Cancer Cells

(A) StarBase v.2.0 results showing the sequence of UCA1 with highly conserved putative miR-143-binding sites. (B) miR-143 mimic considerably reduced the luciferase activity of the UCA1-WT luciferase reporter vector compared with NC, while miR-143 mimic did not have any impact on the luciferase activity of UCA1-MUT-transfected cells. (C) UCA1 and miR-143 simultaneously existed in the production precipitated by anti-AGO2. (D) Relative expression of miR-143 in the cisplatin-sensitive group and the cisplatin-resistant group in ovarian cancer patients. (E) Relative expression of miR-143 in a panel of ovarian cancer cell lines. All tests were performed at least three times. Data were expressed as mean ± SD. **p < 0.01.