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. 2019 May 24;17:92–101. doi: 10.1016/j.omtn.2019.05.007

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© 2019 The Author(s)

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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UCA1 Is Secreted into Exosomes Derived from the Sera of Ovarian Cancer Patients

(A) Representative image of exosome (indicated by red arrows), derived from the sera of ovarian cancer patients, detected from electron microscope. (B) The markers of exosome from purified serum exosome were analyzed by western blotting in exosomes (Es) and exosome-depleted supernatant (EDS). (C) qRT-PCR for the abundance of UCA1 in serum exosomes. The levels of UCA1 in serum exosomes from the cisplatin-resistant group were significantly higher than in the cisplatin-sensitive group. (D) In the exosomes extracted from the sera of ovarian cancer patients, the expression levels of UCA1 were negatively correlated with those of miR-143.